General Cell Lines and Cell Cultures
Eurofins Discoverx Ready-to-Assay LPA2 Lysophospholipid Receptor Frozen Cells, 2 Vials of Cells. (HTS207RTA)
The Ready-to-Assay LPA2 Lysophospholipid Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. LPA) based activation of LPAR2 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses LPAR2 alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of LPAR2, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Biochain Institute Inc Frozen Tissue Section - Human Adult Normal: Heart: Ventricle (left), 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's Frozen Tissue Slides are ideal for rapidly identifying cellular localization of RNA or protein. A single human adult normal tissue with 5-10 um thickness is mounted on a positively charged glass slide. The slides are fixed and dehydrated with acetone for consistent results with in situ hybridization and immunohistochemistry. More organs may be available upon request.
Sigma Aldrich Fine Chemicals Biosciences Human Dermal fibroblasts
Dermal fibroblasts are responsible for producing the extracellular matrix forming the connective tissue of the skin and play a crucial role during wound healing. HDf provide an excellent model system to study many aspects of cell physiology and have been utilized in dozens of research publications particularly those related to skin biology and reprogramming/induced pluripotency studies. HDf were used to create along with human synovyocytes induced pluripotent stem cells (iPSC) by using the now classic Yamanaka cocktail of Oct3/4 Sox2 Klf4 and c-Myc the discovery for which Dr. Shinya Yamanaka was awarded the Nobel Prize in 2012 (Takanashi 2007 2009) and to characterize iPSC general properties miRNA expression profiles and differentiation potential (Hayashi 2010 Ohta 2011 Koyanagi-Aoi 2013 Noguchi 20130 Razak 2013 Sakurai 2013 Tanaka 2013 Yanagida 2013)
Biochain Institute Inc Matched Pair - Paraffin Tissue Section - Human Primary Tumor and Normal (PP): Lung, 5 x2 slides /PK
BioChain's human paraffin tissue (FFPE) section matched pair products include: Primary Pair (PP), Primary and Metastatic Pair (PM). PP consists of paraffin tissue sections of primary tumor and its adjacent normal tissue; PM consists of paraffin tissue sections of primary tumor and corresponding metastatic tumor. Paraffin tissue sections in each pair are prepared from the same donor. This product line is ideal for localization of tumor- specific genes and tumor metastatic genes.
Biochain Institute Inc Paraffin Tissue Section - Human Breast Tumor: Medullarycarcinoma of Breast, 5 sides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's formalin fixed paraffin embedded (FFPE) tissue section line encompasses a large selection of tissue sections which are suitable for immunohistochemistry and in situ hybridization assays. The tissue sections are approximately 5 um thick. Each slide contains tissue from a single human tumor. Documentation of tissues' clinical histories may be available upon request. For those customers who want to perform FFPE DNA and RNA isolation, BioChain can provide tissue section slices in tubes instead of mounting them on glass slides.
Biochain Institute Inc Frozen Tissue Section Panel - Human Disease Tissue, Alzheimer's Disease, Multi-tissue II, 7 different tissues, 5 slides/PK
BioChain's neurological diseased frozen tissue panels are designed for studying Alzheimer, Parkinson's Disease, Dementia, Multiple Sclerosis, Progressive Supranuclear Palsy (PSP), and Depression diseases. 6-8 same diseased frozen tissues with 5-10 um thickness are mounted on a positively charged glass slide. The slides are fixed and dehydrated with acetone for consistent results with in situ hybridization and immunohistochemistry.
Biochain Institute Inc Frozen Tissue Section Panel - Human Adult Normal Tissue, Multi-tissue III, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. The tissues are immediately put in liquid nitrogen after being excised, and then identified by a board-licensed pathologist. Patient demographic and disease related history data is available. BioChain's Frozen Tissue Panels are manufactured using high-quality tissues. 5 to 8 different tissues are mounted on a modified glass slide after preparation with proprietary techniques. Each section is approximately 5 um thick. H.E. staining, immunostaining, and in situ hybridization with proliferating cellular nuclear antigen (PCNA) antibody and P53 gene probe ensure the quality of tissue panels. It is an ideal product for rapid cellular localization of RNA and protein expression.
Biochain Institute Inc Matched Pair - Total RNA - Human Primary Tumor and Normal Tissue: Lung, 2x10 ug/PK
BioChain's human total RNA matched pair products include: Primary Pair (PP), Primary and Metastatic Pair (PM). PP consists of total RNA isolated from primary tumor and its adjacent normal tissue; PM consists of total RNA from primary tumor and and corresponding metastatic tumor. Total RNA in each pair is prepared from the same donor. This product line is designed for identifying tumor-specific genes and tumor metastatic genes.
Biochain Institute Inc Paraffin Tissue Section - Parkinson's Disease: Brain: Postcentral Gyrus, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's formalin fixed paraffin embedded (FFPE) tissue section line encompasses a large selection of tissue sections which are suitable for immunohistochemistry and in situ hybridization assays. The tissue sections are approximately 5 um thick. Each slide contains tissue from single human diseased sample. Documentation of tissues' clinical histories may be available upon request. For those customers who want to perform FFPE DNA and RNA isolation, BioChain can provide tissue section slices in tubes instead of mounting them on glass slides.
Amsbio LLC Human Colon Normal FFPE Tissue Block
Human FFPE tissue blocks are processed from diseased tissues or clinically-unremarkable donor normal human tissue samples. Tissue is prepared by a certified medical pathologist, fixed in 10% neutral formalin for 24 hours and embedded in IHC-grade paraffin. The target FFPE specimen size is 0.5 x 0.5 x 0.5 cm, but it can vary significantly depending on the organ.
Promocell GmbH PromoCell HUtSMC-c 500,000 Human Uterine Smooth Muscle Cells, cryopreserved
Primary Human Uterine Smooth Muscle Cells (HUtSMC) are isolated from the myometrium (the middle layer of the uterine wall) and stain positive for smooth muscle α-actin. During pregnancy, hormones and growth factors cause an extensive hypertrophy of uterine smooth muscle cells.This and other morphological and biochemical effects on the uterus can be studied in vitro using HUtSMC.Our HUtSMC are now also available from HLA-typed donors.
Biochain Institute Inc Paraffin Tissue Section - Human Adult Normal: Appendix, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's formalin fixed paraffin embedded (FFPE) tissue section line encompasses a large selection of tissue sections which are suitable for immunohistochemistry and in situ hybridization assays. The tissue sections are approximately 5 um thick. For those customers who want to perform FFPE DNA and RNA isolation, BioChain can provide tissue section slices in tubes instead of mounting them on glass slides.
Genscript Corporation CHO-K1/NK1 Stable Cell Line
Tachykinins are peptides sharing the common C-terminal amino acid sequence Phe-X-Gly-Leu-Met-NH sub 2 /sub This neuropeptide family is composed of substance P neurokinin A and neurokinin B which are widely distributed in mammalian central and peripheral nervous systems It plays a role as both a neurotransmitter and a neuromodulator Their actions are mediated by binding with three distinct receptors namely NK1 NK2 and NK3 NK1 has high affinity with substance P In the CNS NK1 has been implicated to play a role in regulating neuronal survival and degeneration In the cardiovascular system NK1 mediates endothelium-dependent vasodilatation and plasma protein extravasations In the gastrointestinal system NK1 receptors mediate intestinal motility secretion and vascular functions SP-NK1 receptor communication is also involved in glioma development and progression NK1 receptor antagonists may have several therapeutic applications in diseases mediated by tachykinins such as
Biochain Institute Inc Paraffin Tissue Section - Human Brain Tumor: Pituitary Adenoma with Oncocytic Cell Type, 5 sides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's formalin fixed paraffin embedded (FFPE) tissue section line encompasses a large selection of tissue sections which are suitable for immunohistochemistry and in situ hybridization assays. The tissue sections are approximately 5 um thick. Each slide contains tissue from a single human tumor. Documentation of tissues' clinical histories may be available upon request. For those customers who want to perform FFPE DNA and RNA isolation, BioChain can provide tissue section slices in tubes instead of mounting them on glass slides.
ATCC CCD 841 CoN; Colon; Human (Homo sapiens)
CCD 841 CoN cells were isolated from normal human colon tissue. The cells resemble epithelial cells; however, the cells do not contain keratin and definitive evidence of epithelial origin is lacking.